Pharmacokinetic interactions of maraviroc with darunavir-ritonavir, etravirine, and etravirine-darunavir-ritonavir in healthy volunteers: results of two drug interaction trials.
Kakuda TN, Abel S, Davis J, et al.
Antimicrob Agents Chemother, 2011, 55(5): 2290-2296.

The pharmacokinetic interactions between maraviroc and darunavir/ritonavir, maraviroc and etravirine and maraviroc and darunavir/ritonavir/etravirine were investigated in phase I, randomized, two-period crossover studies in healthy volunteers.

Coadministration of maraviroc (150 mg twice daily) and darunavir/ritonavir (600/100 mg twice daily) increased maraviroc AUC, Cmax and Cmin by 4.05-fold, 2.29-fold and 8.00-fold respectively.  Darunavir and ritonavir concentrations were consistent with historical data.  Coadministration of maraviroc (300 mg twice daily) and etravirine (200 mg twice daily) decreased maraviroc AUC, Cmax and Cmin by 53%, 60% and 39% respectively.  Maraviroc had no effect on etravirine pharmacokinetics.  Coadministration of maraviroc (150 mg twice daily) and darunavir/ritonavir/etravirine (600/100/200 mg twice daily) increased maraviroc AUC, Cmax and Cmin by 3.10-, 1.76- and 5.27-fold, respectively.  Maraviroc had no effect on etravirine pharmacokinetics, nor darunavir Cmax, nor ritonavir AUC and Cmax, but decreased darunavir AUC and Cmin by 15% and 23%, and decreased ritonavir Cmin by 26%.

Maraviroc can be coadministered with etravirine, darunavir/ritonavir, or etravirine/darunavir/ritonavir. Maraviroc should be dosed at 600 mg twice daily with etravirine in the absence of a potent CYP3A inhibitor (i.e., a boosted protease inhibitor) or at 150 mg twice daily when coadministered with darunavir/ritonavir with or without etravirine.