Slide 4 of 22
Speaker notes: Looking at the PK of a single protease inhibitor there is the problem that, at the end of a dosing interval, the concentration of drug in plasma falls to a level close to the area of potential replication. The terminology used varies somewhat:
	Cmin or Ctrough: The lowest concentration reached during the dosing interval tend to be used interchangeably and can usually be considered to mean the same thing there are occasional exceptions to this rule eg nelfinavir (NFV) where Cmin is not always the same as Ctrough. IC50 or EC50 or IC95: The concentration required to inhibit 50% or 95% of the virus, respectively generated in vitro most pharmacologists use IC50 as the most reliable parameter, but IC90 and IC95 are also used.

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