Slide 5 of 22

Speaker notes: Cmin is generated from in-vivo PK data. IC50 or IC95 are generated in vitro, increasing drug concentration until 50% or 95% of the virus is inhibited how close the IC50 and IC95 values are to each other depends on how steep the curve is (right-hand graph) how reliable the values are depends on the system used to measure them. IQ (inhibitory quotient): IQ = concentration in plasma/concentration required for inhibition a very important term, describing the trough plasma concentration of drug over the concentration of drug needed to inhibit the virus to a certain degree in vitro gives an index of how far the concentration of a drug in vivo is in excess of the viral IC50.

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