Slide 13 of 22

Speaker notes: This shows in-vitro data obtained in the same system, hence they are directly comparable. The data show IC95 values of wild-type virus for all PIs (column 1). These values are multiplied by the fold-attenuation of the drug by human serum (column 2). Taking into account the effect of the protein in human serum mimics the in-vivo situation; hence we get a set of 'corrected' IC95 values (column 3) expressed either in nM or ng/mL. Note that all values in the table are mean values and subject to large variability. How to translate these in-vitro data into an approach to therapeutic drug monitoring (TDM) in the clinic is still being established; the IC95 values are changing all the time as research goes on, and the minimum drug concentrations desired in clinical practice will change accordingly.

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