Slide 14 of 22

Speaker notes: Cmin data come from the Liverpool data base for the first 5 PIs, with the Cmin value for ABT-378 being provided by Abbott. IC95 data come from recent publications by Molla (1998) and Condra (2000). Combining these Cmin and IC95 data give an inhibitory quotient (IQ) for the different PIs. Although the values will be subject to marked variability, it is the rank order of IQs which is important, and clearly with ABT-378/r there is a great deal of leeway (larger therapeutic margin) when compared with single PIs: value of ~40 for ABT-378/r compared with values of less than 5.

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