Slide 15 of 22

Speaker notes: This histogram translates the inhibitory quotient (IQ) values from the previous table, showing again how marked the difference is between ABT-378/r and other PIs. Previous table showed: Cmin data from the Liverpool data base for the first 5 PIs, with the Cmin value for ABT-378 being provided by Abbott IC95 data from recent publications by Molla (1998) and Condra (2000) the combination of Cmin and IC95 data to give an inhibitory quotient for the different PIs Although the IQ values vary somewhat according to techniques used, it is the rank order of IQs which is important, and clearly with ABT-378/r there is a great deal of leeway (larger therapeutic margin) when compared with single PIs value of ~40 for ABT-378/r compared with values of less than 5.

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