Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Amyl nitrate is metabolized rapidly by hydrolytic denitration. Lenacapavir does not interact with this metabolic pathway.

Coadministration has not been studied based on metabolism and clearance a clinically significant interaction is unlikely. Fostemsavir is a prodrug and is hydrolysed to the active compound temsavir in the small intestine. Temsavir is mainly metabolized by esterase-mediated hydrolysis with a small contribution of CYP3A4. Lenacapavir is mainly cleared as unchanged drug and is a moderate inhibitor of CYP3A4 but is unlikely to significantly alter fostemsavir pharmacokinetics.