Interaction Checker

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Prescribing Resources

We have produced a series of materials in PDF format to aid prescribing.

Treatment Selectors show interactions between key antiretrovirals and drugs used to treat a range of common comorbidities.

Prescribing and Dosing Guidance give advice and recommendations for the use of HIV drugs in specific patient populations.

Interactions Explained describe the pharmacology of different mechanisms of interaction that may occur with HIV therapy.

Interaction Summary Tables provide an overview of interactions between HIV drugs and the comedications listed in the interaction checker.

Pharmacokinetic Fact Sheets contain information on the pharmacokinetics, metabolism and disposition of HIV drugs and have been collated from product labels and published literature on licensed doses (unless otherwise stated).

Please click on the headings below to see the full range of resources within each section.

Treatment Selectors (by therapeutic indication)

Analgesics

Updated June 2022

Anticoagulants & Antiplatelets

Updated June 2022

Antidepressants

Updated June 2022

Anti-Diabetics

Updated June 2022

Anti-Malarials

Updated June 2022

Antipsychotics

Updated June 2022

Anti-Tuberculosis Drugs

Updated June 2022

Anxiolytics & Hypnotics

Updated June 2022

Beta Blockers

Updated June 2022

Bronchodilators for COPD

Updated June 2022

Calcium Channel Blockers

Updated June 2022

Cancer Therapies

Updated June 2022

Contraceptives

Updated June 2022

Corticosteroids

Updated June 2022

Herbal and Mineral Supplements

Updated June 2022

Hormone Replacement Therapy (HRT)

Updated June 2022

Hypertensives

Updated June 2022

Immunosuppressants for SOT

Updated June 2022

Lipid Lowering

Updated June 2022

Pulmonary Anti-hypertensives

Updated June 2022

ARVs and Recreational Drugs

Updated June 2022

Prescribing and Dosing Guidance

ARVs for patients with swallowing difficulties

Updated March 2022

ARV absorption and gastric surgery

Updated February 2022

Interactions with FTC/TDF PrEP and long-term use medications

Updated November 2021

Interactions with hormone therapy for gender affirmation

Updated November 2021

Guidance for the use of non-oral steroids and strong CYP3A4 inhibitors

Updated September 2021

Prescribing guidance for elderly PLWH

Updated July 2019

ARVs and food requirements

Updated July 2019

Dosing of ARVs for patients with renal impairment

Updated March 2022

Dosing of selected non-ARVs for patients with renal impairment

Updated July 2019

Interaction potential of chemsex drugs

Updated November 2018

Considerations and interactions when switching from ritonavir-boosted to cobicistat-boosted atazanavir or darunavir

Updated October 2017

Interactions Explained

Interactions with herbal and mineral supplements

Updated December 2021

Interactions with integrase inhibitors and cations in antacids and supplements/vitamins

Updated December 2021

Interactions following oral or intramuscular administration

Updated June 2021

Dose dependent enzyme induction

Updated February 2021

Interaction Summary Tables

Interactions with Protease Inhibitors

Updated June 2022

Interactions with NNRTIs

Updated June 2022

Interactions with NRTIs

Updated June 2022

Interactions with Integrase Inhibitors

Updated June 2022

Interactions with Entry and Attachment Inhibitors

Updated June 2022

Interactions between key ARVs

Updated June 2022

Pharmacokinetic Fact Sheets

Abacavir (ABC)

Updated March 2016

Atazanavir

Updated March 2016

Bictegravir

Updated October 2018

Cabotegravir (IM)

Updated February 2021

Cabotegravir (oral)

Updated February 2021

Cobicistat

Updated March 2016

Dapivirine (vaginal ring)

Updated July 2021

Darunavir

Updated October 2018

Dolutegravir

Updated March 2016

Doravirine

Updated October 2018

Efavirenz

Updated March 2016

Elvitegravir

Updated March 2016

Emtricitabine (FTC)

Updated March 2016

Etravirine

Updated March 2016

Fostemsavir

Updated July 2021

Lamivudine (3TC)

Updated March 2016

Lopinavir

Updated March 2016

Maraviroc

Updated March 2016

Nevirapine

Updated March 2016

Raltegravir

Updated March 2016

Rilpivirine (IM)

Updated February 2021

Rilpivirine (oral)

Updated February 2021

Ritonavir

Updated March 2016

Tenofovir-DF (TDF)

Updated March 2016

Zidovudine

Updated March 2016

Drug Interactions with 3HP for TB

Drug interaction summary tables and interaction notes for weekly isoniazid/rifapentine (3HP)

Updated October 2021
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