Delstrigo (doravirine, lamivudine, tenofovir-DF) is indicated for use as a complete regimen for the treatment of HIV-1 infection. However, in specific clinical situations where an intensification of HIV treatment is needed, coadministration with darunavir/cobicistat would be possible from a pharmacokinetic standpoint, but with close monitoring for tenofovir-associated adverse events. Coadministration with ritonavir increased doravirine AUC by 3.5-fold and Cmin by 2.9-fold and a similar increase may occur with cobicistat. No dose adjustment of doravirine is required as phase I trials showed a good tolerability of doravirine with up to a 3- to 4-fold increase in exposure. Boosted PIs were shown to increase tenofovir-DF and there are currently inadequate data to determine whether tenofovir-DF plus cobicistat is associated with a greater risk of renal adverse reactions than tenofovir-DF without cobicistat. The European SPC for tenofovir-DF advises close renal monitoring of patients receiving tenofovir-DF with a cobicistat-boosted protease inhibitor. The US Prescribing Information for cobicistat does not recommend coadministration of cobicistat and tenofovir-DF in combination with concomitant or recent use of a nephrotoxic agent. Note, cobicistat has been shown to decrease estimated creatinine clearance due to inhibition of tubular secretion of creatinine and should not be initiated in patients with creatinine clearance less than 70 ml/min if tenofovir-DF requires dose adjustment based on creatinine clearance.