Do Not Coadminister
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Atazanavir alone (ATV)
Quality of Evidence: Very Low
Coadministration has not been studied and is not recommended. The US product label for emtricitabine/tenofovir-DF states that atazanavir should not be given alone with emtricitabine/tenofovir-DF, but should be administered at a dose of 300 mg once daily with ritonavir 100 mg once daily. Coadministration of tenofovir-DF (300 mg once daily) and atazanavir alone (400 mg once daily) decreased atazanavir AUC, Cmax and Cmin by 25%, 21% and 40%, respectively (n=34); tenofovir AUC, Cmax and Cmin increased by 24%, 14% and 22%, respectively (n=33).