Coadministration of rilpivirine (25 mg once daily) and tenofovir alafenamide (25 mg once daily) had no significant effect on the pharmacokinetics of rilpivirine (AUC and Cmin increased by 1% and 13%, Cmax decreased by 7%). Tenofovir alafenamide Cmax and AUC were unchanged. Tenofovir Cmax, AUC and Cmin increased by 13%, 11% and 18%, respectively. No dose adjustment of tenofovir alafenamide or rilpivirine is required.