Liverpool HIV Interactions

Interaction Checker

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Potential Weak Interaction

Rilpivirine (RPV)

Dolutegravir/Lamivudine (DTG/3TC)

Quality of Evidence: Very Low

Summary:

Dovato (dolutegravir/lamivudine) is indicated for use as a complete regimen for the treatment of HIV 1 infection. However, in specific clinical situations where an intensification of HIV treatment is needed, coadministration with rilpivirine would be possible from a pharmacokinetic standpoint. Coadministration of rilpivirine (25 mg once daily) and dolutegravir (50 mg once daily) increased dolutegravir Cmax, AUC and Ctrough by 13%, 12% and 22%, respectively. Rilpivirine Cmax, AUC and Ctrough increased by 10%, 6% and 21%, respectively. No interaction is expected with lamivudine.

Description:

Coadministration of dolutegravir and rilpivirine increased dolutegravir AUC, Cmax and Cmin by 12%, 13% and 22%, respectively. There was no change in rilpivirine pharmacokinetics. No dose adjustment is necessary.

Dovato Summary of Product Characteristics, ViiV Healthcare, July 2019.

Dovato is a complete regimen for the treatment of HIV-1 infection; therefore, coadministration with other antiretroviral drugs for the treatment of HIV-1 infection is not recommended.

Dovato US Prescribing Information, ViiV Healthcare, April 2019.

Coadministration of dolutegravir (50 mg once daily) and rilpivirine (25 mg once daily) was studied in 16 HIV-negative subjects. Rilpivirine increased dolutegravir AUC, Cmax and Ctrough by 12%, 13% and 22%, respectively. Similarly, rilpivirine AUC, Cmax and Ctrough increased by 6%, 10% and 21%, respectively, in the presence of dolutegravir. Dolutegravir and rilpivirine can be coadministered without dosage adjustment for either agent.

Lack of pharmacokinetic interaction between rilpivirine and integrase inhibitors dolutegravir and GSK1265744. Ford SL, Gould E, Chen S, et al. Antimicrob Agents Chemother, 2013, 57(11):5472-7.

View all available interactions with Rilpivirine (RPV) by clicking here.