No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Nicotinamide (Niacinamide) [alone]
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Nicotinamide is metabolized by nicotinamide methyltransferase to N-methylnicotinamide which is then metabolized by xanthine oxidase and aldehyde oxidase. Renal elimination of unchanged nicotinamide is minimal, therefore, there is little potential for an interaction with emtricitabine and tenofovir-DF via competition for renal elimination pathways.
View all available interactions with
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking