No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Polatuzumab vedotin is an antibody-drug conjugate comprising a monoclonal antibody and monomethyl auristatin E (MMAE), a potent chemotherapeutic agent. The monoclonal antibody undergoes elimination via intracellular catabolism and does not interact with emtricitabine/tenofovir-DF. MMAE is a substrate of CYP3A4 and P-gp but emtricitabine/tenofovir-DF does not interfere with these pathways.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking