No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Black cohosh (Actaea racemosa, Cimicifuga racemosa)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance, a clinically significant interaction is unlikely. No effect on tenofovir-DF (the prodrug of tenofovir) is expected as black cohosh had no significant effect on the pharmacokinetics of digoxin (a P-gp substrate).
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