Potential Weak Interaction
Quality of Evidence:
Coadministration has not been studied. Pretomanid is metabolized in the liver via multiple reductive and oxidative pathways with CYP3A4 mediated metabolism representing 20% of its metabolism. Coadministration with lopinavir/ritonavir was shown to reduce pretomanid exposure by 17% and a similar effect is expected with ritonavir. No a priori dosage adjustment is needed for pretomanid.
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