Coadministration has not been studied but a clinically significant interaction is unlikely. No dosage adjustment is necessary.

Dolutegravir may be coadministered with PPIs or H2-antagonists without dose adjustment as solubility of dolutegravir is not influenced by changes in gastric pH and coadministration with omeprazole had minimal effect on dolutegravir exposure. Coadministration of omeprazole (40 mg once daily) and single doses of dolutegravir (50 mg single dose, administered 2 hours after omeprazole) was studied in 12 HIV-negative subjects and had no significant effect on dolutegravir exposure (no change in AUC, 8% decrease in Cmax, 5% decrease in Cmin).