Interaction Checker
No Interaction Expected
Nevirapine (NVP)
Maraviroc (MVC)
Quality of Evidence: Very Low
Summary:
The recommended dose of maraviroc when coadministered with nevirapine is 300 mg twice daily. When compared to historical data, coadministration of a single dose of maraviroc (300 mg) to HIV+ subjects stable on a nevirapine containing regimen had no effect on maraviroc AUC and increased Cmax by 54%. Nevirapine concentrations were not measured, but no effect is expected.
Description:
Coadministration of nevirapine and maraviroc (300 mg single dose) had no effect on maraviroc AUC and increased Cmax by 54% compared to historical controls. Nevirapine concentrations were not measured, but no effect is expected. Maraviroc and nevirapine can be coadministered without dose adjustments.
Viramune Summary of Product Characteristics, Boehringer Ingelheim Ltd, November 2019.
Coadministration of nevirapine (200 mg twice daily) and maraviroc (300 mg single dose) was studied in 8 subjects. Compared to historical controls, maraviroc AUC increased by 1% and Cmax increased by 54%. The effect on nevirapine pharmacokinetics was not significant when compared to historical controls.
Viramune Prescribing Information, Boehringer Ingelheim Pharmaceuticals Inc, October 2019.
Comparison to exposure in historical controls suggests that maraviroc 300 mg twice daily and nevirapine can be co-administered without dose adjustment. When compared to historical controls, coadministration of nevirapine (200 mg twice daily) and maraviroc (300 mg single dose) resulted in no change in maraviroc AUC and an increase in Cmax. Nevirapine concentrations were not measured, but no effect is expected.
Celsentri Summary of Product Characteristics, ViiV Healthcare, September 2018.
When maraviroc (300 mg single dose) was coadministered with nevirapine (200 mg twice daily) and lamivudine/tenofovir, there was no effect on nevirapine AUC and a 54% increase in Cmax, compared to historical data. The recommended dose of maraviroc when coadministered with nevirapine is 300 mg twice daily.
Selzentry Prescribing Information, ViiV Healthcare, July 2018.
Coadministration of maraviroc (300 mg single dose) to HIV+ subjects stable on a nevirapine containing regimen (200 mg twice daily with 3TC/TDF, n=8) had no effect on maraviroc AUC, but increased Cmax by 54% when compared to historical data.
A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of UK-427,857 in HIV+ subjects. Muirhead G, et al. 12th Conference on Retroviruses and Opportunistic Infections, Boston, February 2005, abstract 663.
View all available interactions with Nevirapine (NVP) by clicking here.
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