Liverpool HIV Interactions

Interaction Checker

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No Interaction Expected

Rilpivirine (RPV)

Paracetamol (Acetaminophen)

Quality of Evidence: Moderate

Summary:

Coadministration of rilpivirine (150 mg once daily) and paracetamol (500 mg single dose) increased rilpivirine Cmax, AUC and Cmin by 9%, 16% and 26%. Paracetamol Cmax and AUC decreased by 3% and 8%. No dose adjustment is needed for either drug. [Note: this interaction study has been performed with a dose higher than the licensed dose for rilpivirine assessing the maximal effect on the co-administered drug. The dosing recommendation is applicable to the licensed dose of rilpivirine 25 mg once daily.]

Description:

Coadministration of paracetamol (500 mg single dose) and a higher than the recommended dose of rilpivirine had no effect on paracetamol AUC or Cmax. Rilpivirine AUC and Cmax were unchanged, but Cmin increased by 26%. No dose adjustment is required.

Edurant Summary of Product Characteristics, Janssen-Cilag Ltd, January 2019.

Coadministration of rilpivirine (150 mg once daily) and paracetamol (500 mg single dose) was studied in 16 subjects. Rilpivirine Cmax, AUC and Cmin increased by 9%, 16% and 26%, respectively. Paracetamol Cmax and AUC decreased by 3% and 8%, respectively. No dose adjustment is needed for either drug.

Edurant PUS Prescribing Information, Janssen Therapeutics, May 2019.

Coadministration of rilpivirine (150 mg once daily) and paracetamol (500 mg single dose) was studied in 16 HIV-negative subjects. Rilpivirine Cmax, AUC and Cmin increased by 9%, 16% and 26%, respectively. Paracetamol Cmax and AUC decreased by 3% and 8%, respectively.
van Heeswijk RPG, et al. The effects of TMC278, a next generation non-nucleoside reverse transcriptase inhibitor, on the pharmacokinetics of acetaminophen and CYP2E1 activity in HIV-negative volunteers. 8th International Workshop on Clinical Pharmacology of HIV Therapy, Budapest, April 2007, abstract 67.

View all available interactions with Rilpivirine (RPV) by clicking here.