No Interaction Expected
Quality of Evidence:
This interaction has not been studied. Based on the metabolism/elimination and toxicity profiles of both drugs, there is little potential for interaction. Three clofazimine metabolites, two glucuronides, have been identified in urine, however clofazimine is largely excreted unchanged in the faeces, both as unabsorbed drug and via biliary excretion. As glucuronidation has a minor role in clofazimine elimination, interaction with abacavir via this mechanism is unlikely.
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