Coadministration has not been studied but based on metabolism and clearance a pharmacokinetic interaction is unlikely. However, agranulocytosis, thrombocytopenia, leukopenia, and aplastic anaemia, bone marrow depression, pancytopenia have been reported with acetazolamide therapy. Anaemia, neutropenia and leucopenia can be expected to occur in patients receiving zidovudine. If concomitant treatment with potentially myelosuppressive drugs is necessary then extra care should be taken in monitoring renal function and haematological parameters.