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Do Not Coadminister

Nevirapine (NVP)

Elvitegravir/Cobicistat/ Emtricitabine/Tenofovir-DF (EVG/c/FTC/TDF)

Quality of Evidence: Very Low

Summary:

Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir-DF) is indicated for use as a complete regimen for the treatment of HIV 1 infection and must not be administered with other antiretroviral products. Stribild should not be used in conjunction with non-nucleoside reverse transcriptase inhibitors due to potential drug-drug interactions including altered and/or suboptimal pharmacokinetics of cobicistat, elvitegravir, and/or the coadministered antiretroviral products.

Description:

Stribild is indicated for use as a complete regimen for the treatment of HIV 1 infection and must not be administered with other antiretroviral products.
Stribild Summary of Product Characteristics, Gilead Sciences International Ltd, November 2021.

Stribild is a complete regimen for the treatment of HIV-1 infection; therefore, Stribild should not be administered with other antiretroviral medications for treatment of HIV-1 infection.
Stribild Prescribing Information, Gilead Sciences Inc, September 2021.

This interaction has not been studied. Cobicistat, a cytochrome P450 3A inhibitor significantly inhibits hepatic enzymes, as well as other metabolic pathways. Therefore coadministration would likely result in altered plasma levels of cobicistat and nevirapine. Coadministration of nevirapine with elvitegravir in combination with cobicistat is not recommended.
Viramune Summary of Product Characteristics, Boehringer Ingelheim Ltd, November 2019.

View all available interactions with Nevirapine (NVP) by clicking here.

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