No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration with emtricitabine/tenofovir has not been studied. Coadministration of tenofovir-DF had no clinically significant effect on the pharmacokinetics of methadone (AUC and Cmax increased by 5%). Based on data from lamivudine and tenofovir a clinically significant interaction is unlikely with emtricitabine. No dose adjustment of methadone is required.
Coadministration of methadone and tenofovir disoproxil fumarate increased methadone AUC and Cmax both by 5%. No dose adjustment of methadone is required.
Truvada Summary of Product Characteristics Gilead Sciences Ltd, June 2018.
No clinically significant drug interactions have been observed between TDF and methadone.
Truvada US Prescribing Information, Gilead Sciences Inc, May 2018.
View all available interactions with
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking