Potential Weak Interaction
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Cefalexin is predominantly eliminated unchanged renally by glomerular filtration and tubular secretion via OAT1 and MATE1. A clinically significant interaction due to competition for MATE1 is unlikely with emtricitabine as it has a wide safety margin. However, there is potential competition for OAT1 between cefalexin and tenofovir, which could lead to increased concentrations of either drug.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking