No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Doxycycline is excreted in the urine and faeces as unchanged active substance (40- 60% of an administered dose can be accounted for in the urine). Studies indicate that administration of doxycycline at the recommended doses does not lead to excessive accumulation in patients with renal impairment. There is therefore little potential for a clinically significant interaction with emtricitabine and tenofovir via competition for renal elimination transport mechanisms.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking