No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Like other proteins, streptokinase is metabolised proteolytically in the liver and eliminated via the kidneys. Renal elimination of unchanged streptokinase is minimal and there is little potential for an interaction with emtricitabine and tenofovir via competition for renal elimination pathways.
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