No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Phenytoin undergoes CYP-mediated metabolism. No interaction is expected with emtricitabine, but phenytoin is an inducer of P-gp and therefore could reduce the absorption of tenofovir-DF. However, based on the results of the interaction study between tenofovir-DF and rifampicin (another inducer of P-gp), phenytoin would be expected to cause only a small decrease in tenofovir-DF.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking