Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a pharmacokinetic interaction is unlikely. Lithium is mainly eliminated unchanged through the kidneys and freely filtered at a rate that is dependent upon the glomerular filtration rate. However, since lithium is nephrotoxic, renal function should be monitored closely and the dosage of emtricitabine/tenofovir-DF adjusted accordingly.
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