Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Flucytosine is metabolised to 5-flurouracil which is further metabolised by dihydropyrimidine dehydrogenase. A pharmacokinetic interaction is unlikely but this enzyme is also involved in the catabolic pathway of pyrimidine analogues and competition could potentially increase haematological toxicity. Monitor haematological parameters and consider dose reduction if required.
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