Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Based on metabolism and clearance a clinically significant effect on ketoconazole is unlikely as it is metabolized by CYP3A4 and ketoconazole is unlikely to affect emtricitabine concentrations. However, ketoconazole is an inhibitor of P-gp and could potentially increase the absorption of tenofovir-DF, thereby increasing the systemic concentration of tenofovir. Monitoring of tenofovir-associated adverse reactions, including frequent renal monitoring, is recommended.
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