Potential Weak Interaction
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Approximately 80% of oral/intravenous doses of eflornithine are excreted unchanged via the kidneys. As there are no available data determining whether excretion is via active tubular secretion or glomerular filtration, there is potential for competition with emtricitabine and tenofovir for active renal transport mechanisms, which may lead to increased levels of either drug. A clinically significant interaction is not expected with topical preparations as less than 1% of topically applied eflornithine is systemically absorbed.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking