Potential Weak Interaction
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Sulfadoxine is rarely used alone, but is usually given in combination with pyrimethamine. In vitro data suggest that pyrimethamine inhibits the renal transporters OCT2 and MATE1 and could potentially decrease renal elimination of emtricitabine (via inhibition of MATE1). No interaction is expected with tenofovir as it is primarily excreted via OAT1 and MRP4. No a priori dosage adjustment is recommended in patients with normal renal function but monitoring for side effects is suggested.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking