No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration with norgestrel as hormone replacement therapy (HRT) has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Norgestrel is a racemic mixture with levonorgestrel being biologically active. Levonorgestrel is metabolized by CYP3A4 and is glucuronidated to a minor extent. Emtricitabine/tenofovir-DF does not interact with these metabolic pathways. In addition, no interaction is expected with estradiol or estrogens administered as part of HRT.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking