No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism clearance a clinically significant interaction is unlikely. African potato was shown to inhibit CYP3A4 and P-gp in vitro and to activate PXR suggesting that inhibition may occur initially followed by induction of CYP3A4 and P-gp when used for extended periods. No interaction is expected with emtricitabine Tenofovir-DF (the prodrug of tenofovir) is a substrate of P-gp, however, rifampicin (a P-gp inducer) had no significant effect on tenofovir and no interaction is expected with African potato.
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