Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Cubeb pepper (Piper cubeba)
Quality of Evidence:
Coadministration has not been studied. Based on metabolism and clearance a clinically significant interaction is unlikely with emtricitabine. However, piperine, a component of Piper cubeba, inhibits intestinal P-gp and could potentially increase absorption of tenofovir-DF, thereby increasing tenofovir systemic concentrations. Monitoring of tenofovir-associated adverse reactions, including frequent renal monitoring, is recommended.
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