Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Liquorice (Glycyrrhiza glabra)
Quality of Evidence:
Coadministration has not been studied. Based on metabolism and clearance, a clinically significant interaction with emtricitabine is unlikely. However, glycyrrhetinic acid (the main active metabolite of glycyrrhizin) was shown to be a strong inhibitor of P-gp in vitro and could potentially increase absorption of tenofovir-DF, thereby increasing tenofovir systemic concentrations. Monitoring of tenofovir-associated adverse reactions, including frequent renal monitoring, is recommended.
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