No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
St John's Wort
Quality of Evidence:
Coadministration has not been studied. Based on metabolism and clearance a clinically significant interaction with emtricitabine is unlikely. St John’s Wort, an inducer of P-gp, could reduce the absorption of tenofovir-DF. However, based on the results of the interaction study between tenofovir-DF and rifampicin (another inducer of P-gp), St John’s Wort would be expected to cause only a small decrease in tenofovir-DF.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking