Potential Weak Interaction
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Furosemide is glucuronidated mainly in the kidney (UGT1A9) and to a lesser extent in the liver (UGT1A1). A large proportion of furosemide is also eliminated unchanged renally (via OATs). In vitro data indicate that furosemide is a weak inhibitor of the renal transporters OAT1/OAT3. No interaction with emtricitabine is expected and any effect on renal elimination of tenofovir is likely to be limited. No a priori dosage adjustment is recommended.
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