No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Hydrochlorothiazide is not metabolised and is cleared by the kidneys via OAT1. Hydrochlorothiazide is unlikely to affect emtricitabine as it is eliminated by different renal transporters. In vitro data indicate that hydrochlorothiazide is unlikely to inhibit OAT1 in the range of clinically relevant drug concentrations and therefore is unlikely to affect the renal elimination of tenofovir.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking