No Interaction Expected
Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Isosorbide dinitrate undergoes extensive first past metabolism, predominantly in the liver. As renal elimination of unchanged drug is a minor pathway, there is little potential for an interaction with emtricitabine and tenofovir due to competition for renal elimination pathways.
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Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP) by clicking