Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Acetazolamide is predominantly excreted unchanged via active renal tubular secretion. No interaction is expected with emtricitabine as emtricitabine and acetazolamide are eliminated by different renal transporters. However in vitro studies have shown acetazolamide may competitively inhibit the renal transporters OAT1, OAT3 and OAT4. Tenofovir is mainly eliminated by OAT1 (and to a lesser extent by OAT3) and concentrations of tenofovir may increase. Close monitoring of renal function is recommended.
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