Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)
Quality of Evidence:
Coadministration has not been studied. Based on metabolism and clearance a clinically significant interaction with emtricitabine is unlikely as foscarnet is cleared mainly by glomerular filtration. However foscarnet is nephrotoxic and tenofovir-DF should be avoided with concurrent or recent use of a nephrotoxic agent. If concomitant use of emtricitabine/tenofovir-DF and nephrotoxic agents is unavoidable, renal function should be monitored closely.
Use of emtricitabine/tenofovir-DF should be avoided with concurrent or recent use of a nephrotoxic medicinal product like foscarnet.
Truvada Summary of Product Characteristics Gilead Sciences Ltd, June 2018.
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