Liverpool HIV Interactions

Interaction Checker

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No Interaction Expected

Emtricitabine/Tenofovir-DF (FTC/TDF, PrEP)

Ribavirin

Quality of Evidence: Very Low

Summary:

Coadministration with emtricitabine/tenofovir-DF has not been studied. Ribavirin is partly metabolized (non CYP mediated) and partly excreted in the urine and an interaction with emtricitabine is not expected. Coadministration of tenofovir-DF (300 mg once daily) and ribavirin (600 mg single dose) had no clinically significant effect on ribavirin pharmacokinetics (AUC increased 26% and Cmax decreased 5%). Tenofovir pharmacokinetics were similar to those observed in previous studies.

Description:

Coadministration of famciclovir and emtricitabine decreased famciclovir AUC and Cmax by 9% and 7%. Emtricitabine AUC and Cmax decreased by 7% and 11%. No dose adjustment of famciclovir is required.

Truvada Summary of Product Characteristics Gilead Sciences Ltd, June 2018.

No clinically significant drug interactions have been observed between FTC and famciclovir. Coadministration of famciclovir (500 mg single dose) and emtricitabine (200 mg single dose) was studied in 12 subjects. There was no change in the Cmax and AUC of emtricitabine or famciclovir.

Truvada US Prescribing Information, Gilead Sciences Inc, May 2018.

The effects of multiple doses of tenofovir (300 mg once daily) on a single dose of ribavirin (600 mg) were evaluated in 22 HIV-negative subjects. Pharmacokinetics of ribavirin were not affected by tenofovir with 90% CI for Cmax (0.89 to 1.01) and AUC (1.06 to 1.17 lying within the equivalence bounds (0.80 to 1.25). Tenofovir pharmacokinetics after ribavirin coadministration were similar to those observed in previous studies.

Absence of clinically relevant pharmacokinetic interaction between ribavirin and tenofovir in healthy subjects. Ramanathan S, et al. J Clin Pharmacol, 2006, 46:559-566.

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