No Interaction Expected
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Trimethoprim is primarily eliminated by the kidney and in vitro data suggest that it inhibits the renal transporters OCT2 and MATE1. A clinically relevant drug interaction is unlikely as tenofovir is excreted by different renal transporters.
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Tenofovir-DF (TDF) by clicking