No Interaction Expected
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Renal clearance is by glomerular filtration and to a lesser extent, active tubular secretion for both imipenem and cilastatin. Probenecid, an inhibitor of renal tubular excretion, had minimal effect on plasma levels of imipenem. There is little potential for an interaction via competition for renal transport mechanisms when imipenem/cilastatin is administered with tenofovir-DF.
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