No Interaction Expected
Quality of Evidence:
Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Approximately 30-40% of a nitrofurantoin dose is excreted rapidly in the urine as unchanged nitrofurantoin and some tubular reabsorption may occur in acid urine. As renal excretion is not the predominant mechanism of elimination, there is little potential for a significant interaction with tenofovir-DF via competition for renal elimination pathways.
View all available interactions with
Tenofovir-DF (TDF) by clicking