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Do Not Coadminister

Lamivudine (3TC)

Elvitegravir/Cobicistat/ Emtricitabine/Tenofovir alafenamide (EVG/c/FTC/TAF)

Quality of Evidence: Very Low

Summary:

Genvoya (elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide) is indicated for use as a complete regimen for the treatment of HIV 1 infection and must not be administered with other antiretroviral products. Furthermore, Genvoya contains emtricitabine and should not be administered with lamivudine due to the risk for intracellular interactions between cytidine analogues such as emtricitabine and lamivudine.

Description:

Genvoya should not be co-administered with other antiretroviral medicinal products. Genvoya should not be administered concomitantly with medicinal products containing lamivudine.

Genvoya Summary of Product Characteristics, Gilead Sciences International Ltd, November 2021.

Genvoya is a complete regimen for the treatment of HIV-1 infection; therefore, coadministration of Genvoya with other antiretroviral medications for treatment of HIV-1 infection should be avoided.

Genvoya US Prescribing Information, Gilead Sciences Inc, September 2021.

Lamivudine should not be administered concomitantly with other cytidine analogues, such as emtricitabine.
Epivir Summary of Product Characteristics, ViiV Healthcare UK Ltd, February 2019.

View all available interactions with Lamivudine (3TC) by clicking here.